DAVIDE CACCHIARELLI
FILIPPO CAUSA
MARIO CESARELLI
SALVATORE COSTANZO
DIEGO DI BERNARDO
FANNY FICUCIELLO
MASSIMILIANO FRALDI
FRANCESCO GENTILE
NINO GRIZZUTI
STEFANO GUIDO
PIER LUCA MAFFETTONE
COSTANTINO MENNA
PAOLO A. NETTI
ROSSANA PASQUINO
MARGHERITA RUOPPOLO
BRUNO SICILIANO
GIOVANNA TOMAIUOLO
ENZA TORINO
MAURIZIO VENTRE |
 |
Davide Cacchiarelli grew up in Rome where he carried out his undergraduate studies in Biotechnology and Biology. He obtained a Master Degree and a Doctorate Degree in Genetics and Molecular Biology from University of Rome “La Sapienza”, working on mechanisms of RNA regulation. In 2011 he moved to The Broad Institute of MIT and Harvard and The Department of Stem Cell and Regenerative Biology at Harvard University to focus his research on the rules governing cell fate transitions and reprogramming using genomic approaches.
He returned to Italy in 2017 thanks to the Armenise Harvard Foundation Career Development Award and now he leads a young research group focused on understanding the dynamics of cell fate decisions at TIGEM, the Telethon Institute of Genetics and Medicine in Naples.
Davide Cacchiarelli’s work aims to identify the mechanisms controlling cell fate decisions during cellular differentiation, conversion and reprogramming, and how such processed are affected by genetic mutations of key regulatory proteins including transcription factors. To achieve this goal he proposes to integrate descriptive, functional and single cell genomics to dissect how genetic elements and their variants impinge on the temporal and spatial control of gene expression.
Davide Cacchiarelli is leading the Laboratory of Integrative Genomics at TIGEM, bringing together an interdisciplinary approach engaging stem cell biology, cellular engineering, genomic approaches and mathematical modeling.
|
|
Link to the unina.it website |
|
SELECTED PUBBLICATIONS: |
|
- Modic M, Cacchiarelli D, Ten Berge D, Integrative biology studies in pluripotent stem cells., Stem Cell Res., 2019
- Giulitti S, Pellegrini M, Zorzan I, Martini P, Gagliano O, Mutarelli M, Ziller MJ, Cacchiarelli D, Romualdi C, Elvassore N, Martello G. Direct generation of human naive induced pluripotent stem cells from somatic cells in microfluidics. Nat Cell Biol., 2019
- Cacchiarelli D, Qiu X, Srivatsan S, Manfredi A, Ziller M, Overbey E, Grimaldi A, Grimsby J, Pokharel P, Livak KJ, Li S, Meissner A, Mikkelsen TS, Rinn JL, Trapnell C. Aligning Single-Cell Developmental and Reprogramming Trajectories Identifies Molecular Determinants of Myogenic Reprogramming Outcome. Cell Syst., 2018
- Cacchiarelli D*, Trapnell C*, Ziller MJ*, Soumillon M, Cesana M, Karnik R, Donaghey J, Smith ZD, Ratanasirintrawoot S, Zhang X, Ho Sui SJ, Wu Z, Akopian V, Gifford CA, Doench J, Rinn JL, Daley GQ, Meissner A, Lander ES, Mikkelsen TS. Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency. Cell., 2015.
- Trapnell C*, Cacchiarelli D*, Grimsby J, Pokharel P, Li S, Morse M, Lennon NJ, Livak KJ, Mikkelsen TS, Rinn JL. The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells. Nat Biotechnol., 2014.
|
|
