LABS
BIOMATERIALS AND TE
CELL-INSTRUCTIVE MATERIALS
ORGANOTYPIC TISSUES
BIOMEDICAL DEVICES
LAB-ON-CHIP/ LAB-ON-DROP
NANOMEDICINE
SYNTHETIC BIOLOGY LAB
BIOROBOTICS LAB
LAB-ON-CHIP/ LAB-ON-DROP
Biological fluids are a “gold mine” of information that can define the physiological state or spot pathologies of individuals. The success of an early and correct diagnosis relies on the effective retrieval of these pieces of information from the fluid. Unfortunately, the concentration of target molecules specific for critical pathologies is usually below the limit of detection of conventional testing apparati. Furthermore, some fluids are available only in small volumes. Along these lines Lab-on-a-Chip (LOC) have emerged as leading technologies that hold the promise to dramatically impact on the next generation of diagnostic devices. LOC refers to a set technologies that enable fulfilling operations, normally requiring a whole laboratory, on a miniaturized scale, within a portable or handheld device. LOCs brings in huge advantages in Diagnostics, Cell Biology, Microbiology and Biochemistry since it requires to process very small volumes of the analyte and tiny quantities of chemicals and reactants. In particular LOC devices related to the vitro diagnostic (IVD) market reaches 45.7 billions $ of global sales in 2012, with projection to reach 65 billions $ in 2017. Within the IVD market, molecular diagnostic and Point-of-Care (POC) device categories are the most emerging. Effective implementation of LOC requires the integration of microfluidics, transport phenomena, surface functionalization and multiphase reactions. The activities carried out in the LOC laboratory focus on the technological aspects related to lab-on-chip applications. In more details, specifically developed technologies and process enable the fabrication of particles for beads-based assays in biological fluids within micro-devices; micro and nanofabrication of microfluidic platforms; simulate the processing conditions; development of read-out schemes to obtain specific signatures of living cells or biomarkers.