LABS
BIOMATERIALS AND TE
CELL-INSTRUCTIVE MATERIALS
ORGANOTYPIC TISSUES
BIOMEDICAL DEVICES
LAB-ON-CHIP/ LAB-ON-DROP
NANOMEDICINE
SYNTHETIC BIOLOGY LAB
BIOROBOTICS LAB
CELL-INSTRUCTIVE MATERIALS
Great improvements have been achieved in the last decades in biomaterials and implant performance in vivo thanks to highly effective surface treatments. In fact, prostheses and implants within the human body invariably elicit a reaction. In some cases the reaction can be abnormal leading to the failure of the implant. For instance, restenosis following percutaneous coronary angioplasty has been evaluated to occur in 10 – 40% of cases, whereas 20% of the hip replacement to over-55 patient require a revision in a 20 year time frame owing to prosthesis mobilization. Therefore it is crucial to provide material surfaces with adequate set of signals, ultimately improving prosthesis integration. For instance, micro and nanotraxutred metallic surfaces to improve osteointegration of orthopaedic prosthesis; drug eluting stents that reduce the recurrence of occlusions in the blood vessel, antifouling treatments on intraocular lenses to improve long term clarity of vision. This is even more relevant in case of tissue engineering applications in which a precise control of cell activities is necessary to allow the development of fully functional tissues in vitro.
The cell instructive Materials Lab integrates engineering concepts with life science principles in order to understand and unravel the biochemical and biophysical signals that regulate and control cell behavior, thus allowing to define more efficient functionalization strategies.